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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4361 | CBL0137 hydrochloride | CBL0137,CBLC137,Curaxin 137,CBL-C137 hydrochloride,Curaxin-137 hydrochloride | Others , NF-κB , p53 |
CBL0137 hydrochloride (Curaxin-137 hydrochloride) activates p53 and inhibits NF-kB (EC50: 0.37/0.47 μM) in the cell-based p53 and NF-kB reporter assays, respectively. It also suppresses histone chaperone FACT. | |||
T4126 | CBL0137 | Curaxin 137,CBLC137 | NF-κB , p53 |
CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the eff... |